J. C. Dallon 1 and H. Paul Ehrlich 2
1: Division of Plastic Surgery, Department of Surgery, Milton S. Hershey Medical Center, Hershey, PA
Permanent address: Department of Mathematics, Brigham Young University,
Provo, UT 84602
2: Division of Plastic Surgery, Department of Surgery, Milton S. Hershey Medical Center, Hershey, PA
Bell's introduction of the fibroblast populated collagen lattice
(FPCL) has facilitated the study of collagen-cell interactions. As a
result of the numerous modifications of the casting of FPCL's, the
in vivo applications of these in vitro findings has been
confusing. Here experimental FPCL contraction findings are viewed in
regard to three proposed mechanisms responsible for lattice
contraction. The cellular mechanisms responsible for generating FPCL
contraction are: cell contraction, cell tractional forces related to
cell locomotion, and initial cell elongation and spreading.
To go back...