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Results from an alignment model where collagen protein directs and is
aligned by fibroblasts. The thin lines represent collagen fibers, the
black dots represent fibroblasts and their tails represent the most
recent path the cell has traversed.
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This figure shows the end results from a wound healing model. The region is a cross section of the wounded dermis. The top of the figure is the surface of the skin. The blue dots represent the location of
fibroblasts (cells responsible for repairing the wound) and the lines
represent the alignment of the extracellular matrix which makes the
dermis. The color of the lines indicates the density of the protein
collagen with red indicating high density and blue indicating low
density.
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Movie (3,698 KB) This is an animation of the type of simulation described above. The region starts out as a wound filled with a blood clot. As the cells enter the region the blood clot is replaced with the collagen based extracellular matrix. (Not all cell locations are shown.)
Movie2 (2,698
KB) This animation is similar to the previous animation but the
cell locations are not shown and the simulation is animated to a later
time.
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